The Liaison Office is an entity, established by a Vice President, in consultation with member nations of his continent, responsible within a certain region to foster and co-ordinate CISM activities in this region and encourage non-member nations in its region to join CISM .

The responsibilities of a Liaison Office within a region are to promote CISM principles, organize the regional calendar,disseminate, adopt, and apply the general instructions of the General Assembly as provided by the Secretary General through the appropriate Vice-President. The Liaison Office must encourage the organization of clinics, congresses, study days, and promote their subsequent use, encourage non-member nations in its region to join CISM, The Vice-President decides on the establishment of a Liaison Office in a CISM active member nation in consultation with the member nations in his continent. He also determines the nations falling under the jurisdiction of a Liaison Office. The staff of a Liaison Office should include a Chief, a Secretary or a Deputy, assistants as required. Liaison Offices shall hold at least one annual plenary meeting of their member nations. A report of this meeting shall be provided to the Vice-President of the continent and to the Secretary General within 30 days. A nation will host a Liaison Office for a period of four (4) years. This period may be extended.
At the present time, there are 12 Liaison Offices : Five are located in Africa (North-Tunisia, Central-Gabon, West-Burkina Faso, Eastern-Kenya, Southern,-South Africa) two in America (North-Barbados and South-Brazil), four in Asia (Middle East –Kuwait, Central-Iran, South East-Thailand, Far East –Rep. of Korea) and one in Europe.